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Novel molecular screening approaches in colorectal cancer


  • The investigators have adhered to the policies for protection of human subjects as prescribed in 45 CFR 46.

  • The views expressed are those of the authors and do not reflect the official policy of the Department of the Army, the Department of Defense or the U.S. Government.


Traditional methods for colorectal cancer (CRC) screening have reduced rates of malignancy and death; however, low compliance and morbidities associated with invasive techniques have encouraged efforts for establishing equally effective, less invasive novel screening approaches. We review the current state of novel screening approaches in CRC to include CT colonography, fecal DNA, DNA methylation, micro-RNA, and protein and molecular markers. J. Surg. Oncol. 2012; 105:459–467. © 2012 Wiley Periodicals, Inc.