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Review Article

Tumor microenvironment and progression

  1. Harold F. Dvorak MD1,*,
  2. Valerie M. Weaver PhD2,
  3. Thea D. Tlsty PhD3,
  4. Gabriele Bergers PhD4

Article first published online: 7 APR 2011

DOI: 10.1002/jso.21709

Issue

Journal of Surgical Oncology

Journal of Surgical Oncology

Special Issue: The Pivotal Role of the Lymphovascular System in Cancer Metastasis

Volume 103, Issue 6, pages 468–474, 1 May 2011

Additional Information

How to Cite

Dvorak, H. F., Weaver, V. M., Tlsty, T. D. and Bergers, G. (2011), Tumor microenvironment and progression. J. Surg. Oncol., 103: 468–474. doi: 10.1002/jso.21709

Author Information

  1. 1

    Department of Pathology, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

  2. 2

    Department of Surgery & Anatomy, Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, California

  3. 3

    Department of Pathology, University of California, San Francisco, California

  4. 4

    Department of Neurological Surgery and Anatomy, Helen Diller Family Cancer Research Building, University of California, San Francisco, California

*Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave. RN227c, Boston, MA 02215. Fax: 617-667-2913.

Publication History

  1. Issue published online: 7 APR 2011
  2. Article first published online: 7 APR 2011
  3. Manuscript Accepted: 16 JUL 2010
  4. Manuscript Received: 2 JUN 2010

Funded by

  • U.S. Public Health Service. Grant Numbers: HL-64402, P01 CA92644
  • National Foundation for Cancer Research
  • US Department of Defense. Grant Numbers: PSOC U54CA143836-01, DOD W81XWH-05-1-0330
  • Susan G. Komen Foundation Postdoctoral Award. Grant Number: PDF124906
  • National Cancer Institute Institutional Training. Grant Number: T32 CA009043
  • Department of Defense Breast Cancer Research Program Concept Award. Grant Number: BC023982
  • National Institutes of Health National Cancer Institute. Grant Numbers: CA097214, CA122024, PS-OC U54
  • U.S. National Cancer Institute. Grant Numbers: R01 CA113382, R01 CA109390

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Keywords:

  • angiogenesis;
  • mechano-biology;
  • patterning

Abstract

Tumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor-A (VEGF-A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis. Also, breast cancers arise as the result of epigenetic as well as genetic changes. Tumor blood vessel pericytes result, in part, from bone marrow precursor cells, and VEGF is a negative regulator of glioblastoma tumor cell invasion. J. Surg. Oncol. 2011;103:468–474. © 2011 Wiley-Liss, Inc.

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