Cancer therapy based on oncogene addiction
Article first published online: 7 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Special Issue: The Pivotal Role of the Lymphovascular System in Cancer Metastasis
Volume 103, Issue 6, pages 464–467, 1 May 2011
How to Cite
McCormick, F. (2011), Cancer therapy based on oncogene addiction. J. Surg. Oncol., 103: 464–467. doi: 10.1002/jso.21749
- Issue published online: 7 APR 2011
- Article first published online: 7 APR 2011
- Manuscript Accepted: 17 AUG 2010
- Manuscript Received: 16 AUG 2010
- targeted therapy;
- oncogene addiction;
- Ras pathway
Tumor cells contain multiple mutations, yet they often depend on continued expressed of a single oncoprotein for survival. Targeting these proteins has led to dramatic responses. Unfortunately, patients usually progress, through drug resistance or adaptive resistance through reprogramming of signaling networks. The Ras-MAPK pathway provides examples of these successes and failures, and has revealed unexpected degrees of oncogene addiction and signaling complexity that are likely to be useful lessons for the future of targeted therapy. J. Surg. Oncol. 2011;103:464–467. © 2011 Wiley-Liss, Inc.