Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma
Article first published online: 22 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 103, Issue 2, pages 148–151, 1 February 2011
How to Cite
Chun, J. M., Kwon, H. J., Sohn, J., Kim, S. G., Park, J.-Y., Bae, H. I., Yun, Y. K. and Hwang, Y. J. (2011), Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma. J. Surg. Oncol., 103: 148–151. doi: 10.1002/jso.21786
- Issue published online: 21 JAN 2011
- Article first published online: 22 DEC 2010
- Manuscript Accepted: 20 SEP 2010
- Manuscript Received: 29 APR 2010
- preoperative serum CRP;
- macroscopic vascular invasion;
- survival after early recurrence
The prognosis of the patients with early recurrence after curative hepatectomy for hepatocellular carcinoma (HCC) is usually dismal.
One hundred twenty-four patients underwent curative resection for HCC at Kyungpook National University Hospital from January 2002 to December 2006. An early recurrence was defined as a recurrence within 2 years after a curative resection. The risk factors associated with an early recurrence were analyzed as well as other risk factors correlated with survival after early recurrence.
Early disease recurrence developed in 56 patients (45.2%). The risk factors associated with an early recurrence were a tumor size larger than 5 cm (P = 0.001) and the presence of tumor micrometastasis (P < 0.001). The 1 year/2 year overall survival, after early recurrence, was 57.0%/41.0% and the preoperative α-fetoprotein, C-reactive protein (CRP), tumor size, macroscopic vascular invasion, and number of tumors were associated with survival on the univariate analysis. The multivariate analysis showed that the independent risk factors for survival, after early disease recurrence, were a preoperative CRP >1.0 mg/dl and macroscopic vascular invasion. (P = 0.004, P < 0.001, respectively).
The preoperative CRP and macroscopic vascular invasion were associated with the aggressiveness of early recurrent HCC. J. Surg. Oncol. 2011; 103:148–151. © 2010 Wiley-Liss, Inc.