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Detection and prognostic impact of micrometastasis in colorectal cancer

Authors

  • Saad Sirop MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • Mohammed Kanaan MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • Alpesh Korant MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • David Wiese MD, PhD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • David Eilender MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • Sunil Nagpal MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • Madan Arora MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • Trevor Singh MD,

    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
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  • Sukamal Saha MD, FACS, FRCS (C)

    Corresponding author
    1. Departments of Surgical Oncology, Internal Medicine, Pathology, and Medical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan
    • 3500 Calkins Road, Suite A, Flint, MI 48532-3685. Fax: 810-230-9607
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Abstract

Review of literature was performed on studies with prognostic impact of micrometastasis in colorectal cancer. Among 16 studies included, micrometastasis was detected in 26.5% of patients. Most analysis revealed that micrometastasis carries a poorer prognosis compared to node negative disease (NND). The results of those studies were compared with our pilot study of 109 patients with colon cancer, showing improved prognosis of micrometastasis after being upstaged and treated with chemotherapy when compared with NND. J. Surg. Oncol. 2011;103:534–537. © 2011 Wiley-Liss, Inc.

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