Woo Seok Kim and Kee-Taek Jang contributed equally to this work.
Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder†
Article first published online: 7 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 103, Issue 3, pages 239–242, 1 March 2011
How to Cite
Kim, W. S., Jang, K.-T., Choi, D. W., Choi, S. H., Heo, J. S., You, D. D. and Lee, H. G. (2011), Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder. J. Surg. Oncol., 103: 239–242. doi: 10.1002/jso.21813
- Issue published online: 15 FEB 2011
- Article first published online: 7 DEC 2010
- Manuscript Accepted: 28 OCT 2010
- Manuscript Received: 16 MAR 2010
- adenosquamous cell carcinoma;
- squamous cell carcinoma;
- gallbladder carcinoma
Backgrounds and Objectives
Adenosquamous/squamous cell carcinoma (AS/SCC) of the gallbladder is rarely encountered and accounts for 1.4–10.6% of all gallbladder carcinomas (GBCs). This study was conducted to investigate the clinicopathologic features of AS/SCC of gallbladder.
The authors retrospectively reviewed 16 cases of pathologically proven AS/SCC of the gallbladder among 404 patients who underwent surgery for GBC from October 1994 to March 2009. Forty-eight conventional GBC patients were selected as controls after matching for age and gender.
Mean patient age was 60.2 years and half were male. Tumor stages in the case group were significantly more advanced than the control group (P < 0.001). R0 resection rates in cases and controls were 50% and 81.2% (P = 0.022). Overall 1-year survival in the case group was significantly poorer than in the control group (18.8% vs. 87.3%, P < 0.001). However, no significant difference in disease-free survival rates was found between cases and controls after R0 resection (P = 0.072).
AS/SCC of the gallbladder is often diagnosed at an advanced stage, which results in non-curative surgical resection and a poorer prognosis than conventional GBC. However, curative surgical resection of AS/SCC of the gallbladder might result in disease-free survival rates that are comparable with those of conventional GBC. J. Surg. Oncol. 2011; 103:239–242. © 2010 Wiley-Liss, Inc.