Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients
Article first published online: 7 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Special Issue: The Pivotal Role of the Lymphovascular System in Cancer Metastasis
Volume 103, Issue 6, pages 518–530, 1 May 2011
How to Cite
Leong, S. P.L., Zuber, M., Ferris, R. L., Kitagawa, Y., Cabanas, R., Levenback, C., Faries, M. and Saha, S. (2011), Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients. J. Surg. Oncol., 103: 518–530. doi: 10.1002/jso.21815
- Issue published online: 7 APR 2011
- Article first published online: 7 APR 2011
- Manuscript Accepted: 27 OCT 2010
- Manuscript Received: 23 OCT 2010
- tumor burden;
- sentinel lymph nodes;
The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes. J. Surg. Oncol. 2011;103:518–530. © 2011 Wiley-Liss, Inc.