Clinically relevant information from sentinel lymph node biopsies of melanoma patients

Authors

  • Duan-Ren Wen MD,

    1. Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California
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    • Researcher.

  • Alistair J. Cochran MD, FRCP (Glasg.), FRCPath (Lond.),

    Corresponding author
    1. Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California
    • Distinguished Professor, Department of Pathology and Laboratory Medicine and Surgery, Johnson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1732. Fax: 310-267-2058.===

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  • Rong-Rong Huang MD,

    1. Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California
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    • Researcher.

  • Eijun Itakura MD,

    1. Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California
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    • Researcher.

  • Scott Binder MD

    1. Department of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California
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    • Professor & Senior Vice-Chair.


  • The authors declare no conflicts of interest.

Abstract

Careful laboratory evaluation of sentinel nodes (SNs) is critical to determine the presence of tumor. This requires evaluation of multiple full-face sections from the SN, using H&E staining and immunohistochemistry. In the future, molecular and genetic approaches may be adjunctive to microscopy. Number of tumor-positive SNs and the amount and location of tumor in SNs correlate with tumor spread to non-sentinel nodes, subsequent recurrences and melanoma death, permitting patient assignment to a risk category. J. Surg. Oncol. 2011; 104:369–378. © 2011 Wiley-Liss, Inc.

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