Clinically relevant information from sentinel lymph node biopsies of melanoma patients†
Article first published online: 19 AUG 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Special Issue: Seminars in Surgical Oncology: Melanoma
Volume 104, Issue 4, pages 369–378, 15 September 2011
How to Cite
Wen, D.-R., Cochran, A. J., Huang, R.-R., Itakura, E. and Binder, S. (2011), Clinically relevant information from sentinel lymph node biopsies of melanoma patients. J. Surg. Oncol., 104: 369–378. doi: 10.1002/jso.21818
The authors declare no conflicts of interest.
- Issue published online: 17 AUG 2011
- Article first published online: 19 AUG 2011
- Manuscript Accepted: 1 NOV 2010
- Manuscript Received: 1 SEP 2010
- New Approaches to Surgical Oncology. Grant Number: #P01-CA-29605
- National Cancer Institute/National Institutes of Health (NCI/NIH)
- sentinel lymph nodes;
- molecular biology;
Careful laboratory evaluation of sentinel nodes (SNs) is critical to determine the presence of tumor. This requires evaluation of multiple full-face sections from the SN, using H&E staining and immunohistochemistry. In the future, molecular and genetic approaches may be adjunctive to microscopy. Number of tumor-positive SNs and the amount and location of tumor in SNs correlate with tumor spread to non-sentinel nodes, subsequent recurrences and melanoma death, permitting patient assignment to a risk category. J. Surg. Oncol. 2011; 104:369–378. © 2011 Wiley-Liss, Inc.