Systemic treatment of early breast cancer—a biological perspective
Article first published online: 7 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Special Issue: The Pivotal Role of the Lymphovascular System in Cancer Metastasis
Volume 103, Issue 6, pages 619–626, 1 May 2011
How to Cite
Greenberg, S., Stopeck, A. and Rugo, H. S. (2011), Systemic treatment of early breast cancer—a biological perspective. J. Surg. Oncol., 103: 619–626. doi: 10.1002/jso.21842
- Issue published online: 7 APR 2011
- Article first published online: 7 APR 2011
- Manuscript Accepted: 24 NOV 2010
- Manuscript Received: 8 NOV 2010
Breast cancer is the most common non-skin cancer affecting women worldwide. In the United States, over 90% of tumors are diagnosed as either in situ or localized to the breast or regional lymph nodes. Surgical treatment and adjuvant radiotherapy play an important role in loco-regional treatment of early stage breast cancer. Systemic adjuvant therapy is targeted towards isolated circulating and/or disseminated tumor cells to prevent systemic recurrence. This review will describe the diverse tumor biology of human breast cancer and how it influences decisions with regard to the use of adjuvant therapies. J. Surg. Oncol. 2011;103:619–626. © 2011 Wiley-Liss, Inc.