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Vascular endothelial growth factors and angiopoietins in presentations and prognosis of papillary thyroid carcinoma

Authors

  • Chuen Hsueh MD,

    1. Department of Pathology, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taiwan, R.O.C.
    2. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taiwan, R.O.C.
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  • Jen-Der Lin MD,

    Corresponding author
    1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taiwan, R.O.C.
    • Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital, 5, Fu-Shin St. Kweishan County, Taoyuan Hsien, Taiwan, R.O.C. Fax: +886-3-3288257.===

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  • I-Chin Wu MS,

    1. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taiwan, R.O.C.
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  • Tzu-Chieh Chao MD, PhD,

    1. Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taiwan, R.O.C.
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  • Jau-Song Yu PhD,

    1. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taiwan, R.O.C.
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  • Miaw-Jene Liou MD,

    1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taiwan, R.O.C.
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  • Chi-Ju Yeh MD

    1. Department of Pathology, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taiwan, R.O.C.
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Abstract

Aims

Angiogenesis from thyroid cancer cell plays the important roles in post-surgical persistent, recurrent, and metastatic papillary thyroid cancer (PTC). This study is to investigate the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tek/Tie-2 receptor, and vascular endothelial growth factors (VEGF) in normal, benign thyroid tissues and different stage of PTC. We expect angiogenetic factors are important in the presentation of local-regional neck or distant metastases in PTC.

Materials and Results

A total of 101 tissues from the subjects underwent thyroidectomy were enrolled in the study. There were 22 control and 79 thyroid cancer patients in different TNM stagings were collected. Ang-1 illustrated highest mean immunostaining score in metastatic group. Comparing with normal and benign thyroid tissues, thyroid cancer tissues illustrated significantly high expression of three angiogenetic factors and Tie-2 receptor. Of the PTC, significantly high expression of three angiogenetic factors and Tie-2 receptor were illustrated in recurrent cases. VEGF showed statistical difference in disease-free cancer mortality, and recurrent groups.

Conclusions

Immunochemical staining illustrated VEGF, Ang-1, Ang-2 expression in PTC tissues related to clinical staging; however, we need more information concerning these factors with long-term follow-up results. J. Surg. Oncol. 2011; 103:395–399. © 2010 Wiley-Liss, Inc.

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