CASP8 −652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population
Article first published online: 9 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 103, Issue 7, pages 716–723, 1 June 2011
How to Cite
Umar, M., Upadhyay, R., Kumar, S., Ghoshal, U. C. and Mittal, B. (2011), CASP8 −652 6N del and CASP8 IVS12-19G>A gene polymorphisms and susceptibility/prognosis of ESCC: A case control study in northern Indian population. J. Surg. Oncol., 103: 716–723. doi: 10.1002/jso.21881
- Issue published online: 26 APR 2011
- Article first published online: 9 FEB 2011
- Manuscript Accepted: 3 JAN 2011
- Manuscript Received: 8 OCT 2010
- Indian Council of Medical Research (ICMR)
- esophageal cancer;
Caspase8 influences carcinogenesis through regulation of apoptosis, hyperproliferation, and metastasis. Role of genetic variations in caspase8 has been explored in various cancers; however, their predictive and prognostic role in esophageal cancer is poorly understood.
We investigated the association of two potential caspase8 polymorphisms: CASP8 −652 6N del and CASP8 IVS12-19 G>A polymorphisms with susceptibility and survival of 259 esophageal squamous cell carcinoma (ESCC) cases and 259 cancer-free controls from northern Indian population using PCR/PCR RFLP method.
CASP8 IVS12-19 AA genotype was found to be associated with significant increased risk of ESCC (odds ratio (OR) 3.28, 95% confidence interval (CI) 1.04–10.29) specifically in male subjects (OR 3.71, 95% CI 1.01–13.35) with lower third tumor anatomical location (OR 6.00, 95% CI 1.60–22.55). Kaplan–Meier and Cox Regression analysis showed lower median survival (7.13 months vs. 25.21 months) and greater hazard of death (HR 3.40, 95% CI 1.38–7.90) with CASP8 IVS12-19 AA genotype in ESCC cases compared to IVS12-19 GG genotype. However, no association of CASP8 −652 6N del polymorphism with susceptibility and prognosis of ESCC was observed.
CASP8 IVS12-19 G>A but not CASP8 −652 6N del polymorphism may modulate risk of ESCC and its survival outcome in northern Indian population. J. Surg. Oncol. 2011;103:716–723. © 2011 Wiley-Liss, Inc.