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Prognostic implication of ezrin expression in esophageal squamous cell carcinoma

Authors

  • Jian-Jun Xie PhD,

    1. Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People's Republic of China
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  • Li-Yan Xu PhD,

    Corresponding author
    1. The Key Immunopathology Laboratory of Guangdong Province, Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, People's Republic of China
    • Li-Yan Xu, The Key Immunopathology Laboratory of Guangdong Province, Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041, People's Republic of China. Fax: +86-754-88900847.===

      En-Min Li, Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou 515041, People's Republic of China. Fax: +86-754-88900847.===

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  • Zhi-Yong Wu MD,

    1. Departments of Oncology Surgery and Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, People's Republic of China
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  • Qing Zhao BSc,

    1. The Key Immunopathology Laboratory of Guangdong Province, Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, People's Republic of China
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  • Xiu-E Xu BSc,

    1. The Key Immunopathology Laboratory of Guangdong Province, Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, People's Republic of China
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  • Jian-Yi Wu BSc,

    1. Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People's Republic of China
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  • Qiao Huang BSc,

    1. Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People's Republic of China
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  • En-Min Li PhD

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, People's Republic of China
    • Li-Yan Xu, The Key Immunopathology Laboratory of Guangdong Province, Institute of Oncologic Pathology, Medical College of Shantou University, Shantou 515041, People's Republic of China. Fax: +86-754-88900847.===

      En-Min Li, Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou 515041, People's Republic of China. Fax: +86-754-88900847.===

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Abstract

Background and Objectives

Ezrin, a member of the ezrin–radixin–moesin family, was implicated in tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including esophageal squamous cell carcinoma (ESCC). The purpose of this study was to explore the clinical significance of ezrin expression in ESCC.

Methods

Ezrin expression was detected on tissue microarrays of ESCC samples in 307 cases using immunohistochemical staining. Survival analysis was assessed by the Kaplan–Meier analysis. Relative risk was evaluated by the multivariate Cox proportional hazards model.

Results

The staining pattern of ezrin was heterogeneous and varied from negative/weakly to intense expression in a cytoplasmic distribution. Kaplan–Meier survival analysis showed that ezrin expression was related to poor overall survival of ESCC patients (P = 0.023). Further analysis revealed that ezrin expression was associated with the survival in the cases of stage III/IV (P = 0.002); but did not influence the survival in the patients of stage I/II. Multivariate Cox analysis demonstrated that ezrin was an independent factor in prognosis of ESCC (P = 0.011).

Conclusions

Ezrin might be a new molecular marker to predict the prognosis of ESCC patients. J. Surg. Oncol. 2011; 104:538–543. © 2011 Wiley-Liss, Inc.

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