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Surgical resection combined with chemotherapy can help achieve better outcomes in patients with primary colonic lymphoma

Authors

  • Yi-Ling Lai MD,

    1. Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
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  • Jen-Kou Lin MD, PhD,

    1. Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
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  • Wen-Yih Liang MD,

    1. Department of Pathology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
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  • Yu-Chung Huang MD,

    1. Division of Hematology–Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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  • Shih-Ching Chang MD, PhD

    Corresponding author
    1. Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
    • Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan. Fax: +886-2-28757639.
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Abstract

Background and Objectives

The colon is a rare location for gastrointestinal non-Hodgkin's lymphoma. We retrospectively analyzed the demographic data of patients with colonic lymphoma and the possible prognostic factors of the disease.

Methods

We studied data obtained from 6,944 patients and performed a retrospective review of patients with primary colonic lymphoma (PCL) by using a pathology registry database. We employed well-established and accepted diagnostic criteria and clinical staging method.

Results

Twenty-nine patients (19 men; 10 women) were diagnosed with PCL. The cecum was the most common tumor location (14/29 patients), and 17 cases (17/29) showed diffuse large–B-cell lymphomas. Four patients died of sepsis within 30 days of an emergency surgery for perforation of intestine. Two-thirds of the patients were in the early disease stages (stages I and II). The overall 5-year survival rate was 47.3%. Disease stage was not a prognostic factor for survival. The overall 5-year survival rate in patients treated with surgery followed by chemotherapy was statistically significant as compared to that in the patients treated with chemotherapy alone.

Conclusion

PCL is a rare malignancy of the gastrointestinal tract, and surgical resection should be considered a part of the standard treatment to achieve a better outcome. J. Surg. Oncol. 2011; 104:265–268. © 2011 Wiley-Liss, Inc.

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