Outcomes of hepatic resection for huge hepatocellular carcinoma (≥10 cm in diameter)
Version of Record online: 4 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 104, Issue 3, pages 292–298, 1 September 2011
How to Cite
Yamashita, Y.-i., Taketomi, A., Shirabe, K., Aishima, S., Tsuijita, E., Morita, K., Kayashima, H. and Maehara, Y. (2011), Outcomes of hepatic resection for huge hepatocellular carcinoma (≥10 cm in diameter). J. Surg. Oncol., 104: 292–298. doi: 10.1002/jso.21931
- Issue online: 1 AUG 2011
- Version of Record online: 4 APR 2011
- Manuscript Accepted: 14 MAR 2011
- Manuscript Received: 14 OCT 2010
- huge hepatocellular carcinoma (larger than 10 cm in diameter;
- HCC ≥ 10 cm);
- hepatic resection;
- morbidity and mortality;
- poor prognostic factors
The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm.
Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = 12). Surgical results for HCC ≥ 10 cm were compared to those of patients with HCC < 10 cm (n = 412). The independent poor prognostic factors of the patients with HCC ≥ 10 cm were identified.
Overall survival was significantly better in patients with hepatic resection for HCC ≥ 10 cm than in those with non-surgical treatment (P < 0.01). Survival rates of patients with hepatic resection for HCC ≥ 10 cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC ≥ 10 cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion.
Hepatic resections for HCC ≥ 10 cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC ≥ 10 cm in T4 appear to be critical. J. Surg. Oncol. 2011; 104:292–298. © 2011 Wiley-Liss, Inc.