Each author participated actively and sufficiently in the study with substantial contributions, critical review, and final approval of the manuscript version being submitted. In addition, all the authors declare that there are no conflicts of interest, financial support, or disclaimers related to this study.
Class II radical hysterectomy for stage I–IIA cervix cancer: Prognostic factors associated to recurrence and survival in a northeast Brazil experience†
Article first published online: 4 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 104, Issue 3, pages 255–259, 1 September 2011
How to Cite
Bezerra, A. L. R., Martins, M. R., Bezerra, S. M. M. d. S., Figueiroa, J. N. and Batista, T. P. (2011), Class II radical hysterectomy for stage I–IIA cervix cancer: Prognostic factors associated to recurrence and survival in a northeast Brazil experience. J. Surg. Oncol., 104: 255–259. doi: 10.1002/jso.21939
- Issue published online: 1 AUG 2011
- Article first published online: 4 APR 2011
- Manuscript Accepted: 16 MAR 2011
- Manuscript Received: 31 JAN 2011
- uterine cervical cancer;
- neoplasm recurrence;
- survival analysis;
- surgical procedure;
- postoperative complications
The main aim of this study was describe the author's experience with class II radical hysterectomy and pelvic lymphadenectomy to treat stage I–IIA cervix cancer and reexamine some prognostic factors associated with disease recurrence and patient survival in this data from northeast Brazil.
A cross-sectional study was carried out on patients treated at our Centers from January 2001 to December 2008. Statistical analyses were performed using conventional methods.
Eighty-eight patients were selected to analysis. Over the 7.3-year follow-up, 80 (91%) patients were alive and 8 (9%) disease recurrences were observed. Overall 1-, 2-, and 5-year patients survival was 96.5%, 95.3%, and 84%, respectively. Recurrence was associated to tumor size ≥1 cm (P = 0.021) and compromised vaginal margin (P = 0.020). Lower survivals were associated to tumor size ≥1 cm (P = 0.038), compromised vaginal margin (P < 0.001), and lymph node metastasis (P = 0.024). Postoperative complications (n = 11) included wound infection (5.7%), partial wound dehiscence (3.4%), and bladder atony (3.4%).
Class II radical hysterectomy has provided appropriated disease control of cervix cancer with low morbidity in our experience. Furthermore, tumor size and compromised vaginal margin were significantly associated to recurrence. These factors and lymph node metastasis were also associated to lower 5-year survival according to our analysis. J. Surg. Oncol. 2011; 104:255–259. © 2011 Wiley-Liss, Inc.