Conflict of Interest Statement: John V. Frangioni: All FLARE technology is owned by Beth Israel Deaconess Medical Center, a teaching hospital of Harvard Medical School. As inventor, Dr. Frangioni may someday receive royalties if products are commercialized. Dr. Frangioni is the founder and unpaid director of The FLARE Foundation, a non-profit organization focused on promoting the dissemination of medical imaging technology for research and clinical use.
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery†
Article first published online: 14 APR 2011
Copyright © 2011 Wiley-Liss, Inc.
Journal of Surgical Oncology
Volume 104, Issue 3, pages 323–332, 1 September 2011
How to Cite
Schaafsma, B. E., Mieog, J. S. D., Hutteman, M., van der Vorst, J. R., Kuppen, P. J.K., Löwik, C. W.G.M., Frangioni, J. V., van de Velde, C. J.H. and Vahrmeijer, A. L. (2011), The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. J. Surg. Oncol., 104: 323–332. doi: 10.1002/jso.21943
- Issue published online: 1 AUG 2011
- Article first published online: 14 APR 2011
- Manuscript Accepted: 19 MAR 2011
- Manuscript Received: 12 JAN 2011
- NIH. Grant Numbers: R01-CA-115296, R01-EB-005805
- Dutch Cancer Society. Grant Number: UL2010-4732
- The Netherlands Organisation for Health Research and Development. Grant Number: 92003526
- optical imaging;
- sentinel lymph node;
- tumour detection
Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery. J. Surg. Oncol. 2011; 104:323–332. © 2011 Wiley-Liss, Inc.