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Type II radical hysterectomy and adjuvant therapy for pelvic lymph node metastasis with stage IB–IIB cervical carcinoma: A retrospective study of 288 patients

Authors

  • Min Zheng MD,

    Corresponding author
    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
    • State Key Laboratory of Oncology in Southern China and Department of Gynecology, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou, Guangdong 510060, P.R. China. Fax: 0086 20 32968086.===

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    • Professor.

  • Long Huang MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
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  • Ji-Hong Liu MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
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    • Professor.

  • Ying Xiong MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
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  • Jun-Dong Li MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
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  • Xin Huang MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
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  • Li He MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
    2. Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong , P.R. China
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  • Yu-Feng Ren MD,

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
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  • Hui-Yun Wang PhD

    1. State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong P.R. China
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    • Professor.


  • Conflict of interest: None

Abstract

Background and Objectives

The aim of this study was to evaluate type II radical hysterectomy with or without adjuvant therapy as a treatment for patients with pelvic lymph node metastasis (PLNM) and stage IB–IIB cervical carcinoma.

Methods

A total of 288 patients with stage IB–IIB cervical carcinoma and confirmed PLNM who underwent a type II radical hysterectomy between 1995 and 2005 were retrospectively evaluated.

Results

The 5-year overall survival (OS) rate for this cohort was 65.6%, and independent prognostic factors identified for PLNM patients included a non-squamous cell histological subtype and parametrial involvement. Survival differences between patients that received or did not receive adjuvant treatment were also evaluated, and the 5-year OS and DFS rates for patients who did not receive adjuvant therapy (47 and 41.4%, respectively) were much lower than the rates for patients who did receive adjuvant therapies (67.7 and 59.4%, respectively). However, these differences were not statistically significant (OS, P = 0.057; DFS, P = 0.080).

Conclusions

Type II radical hysterectomy, in combination with adjuvant therapies, is an efficient treatment for PLNM patients with stage IB–IIB cervical cancer. J. Surg. Oncol. 2011; 104:480–485. © 2011 Wiley-Liss, Inc.

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