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Rationale for complete metastasectomy in patients with stage IV metastatic melanoma


  • David W. Ollila MD,

    Corresponding author
    1. Division of Surgical Oncology and Endocrine Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
    • Associate Professor of Surgery, Department of Surgery, CB #7213 170 Manning Dr., 1150 POB Chapel Hill, NC 27599-7213. Fax: 919-966-8806===

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  • Ana L. Gleisner MD,

    1. Department of Surgery, Saint Louis University, St Louis, Missouri
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    • Resident.

  • Eddy C. Hsueh MD

    1. Division of General Surgery, Saint Louis University, St. Louis, Missouri
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    • Professor of Surgery and Director.


Patients with stage IV melanoma have usually been treated with systemic therapies; however, the overall survival for patients with this approach is disappointing. A complete surgical resection of metastatic disease to stage IV sites offers the best chance to maximize survival. This review article will present data supporting the position that if a complete metastasectomy is technically feasible, then surgery should be strongly considered the first option for properly selected patients with stage IV melanoma. J. Surg. Oncol. 2011; 104:420–424. © 2011 Wiley-Liss, Inc.

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