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Ductal carcinoma in situ (DCIS) of the breast: Perspectives on biology and controversies in current management

Authors

  • Isaac Schmale BS,

    1. Division of Breast and Soft Tissue Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California
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  • Stephen Liu MD,

    1. Division of Medical Oncology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
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  • Jessica Rayhanabad MD,

    1. Division of Breast and Soft Tissue Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California
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  • Christy A. Russell MD,

    1. Division of Medical Oncology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
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  • Dr. Stephen F. Sener MD

    Corresponding author
    1. Division of Breast and Soft Tissue Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California
    • Chief Division of Breast and Soft Tissue Surgery, Norris Cancer Hospital, 1441 Eastlake Avenue, Suite 7415, Los Angeles, California 90033-0800. Fax: 323-865-3539.===

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  • The authors have no conflicts of interest to declare.

Abstract

The incidence of ductal carcinoma in situ (DCIS) has increased because of increasing use of sensitive imaging modalities. MRI is commonly used for the detection of breast cancer but has not yet been validated in randomized trials. There have not been randomized trials addressing optimal margins of excision or axillary sampling. Whole breast radiation after lumpectomy decreases the risk of recurrence but may be omitted in selected patients. Adjuvant Tamoxifen reduces the risk of recurrence but has no impact on overall survival rates. J. Surg. Oncol. 2012; 105:212–220. © 2011 Wiley Periodicals, Inc.

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