Synopsis for Table of Contents: Controversy continues to revolve around appropriate fluid resuscitation during elective major surgery. This manuscript investigates whether volume of intra-operative crystalloids affects outcomes following pancreaticoduodenectomy for pancreatic adenocarcinoma.
Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma†
Article first published online: 25 JUL 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 105, Issue 1, pages 81–84, 1 January 2012
How to Cite
Melis, M., Marcon, F., Masi, A., Sarpel, U., Miller, G., Moore, H., Cohen, S., Berman, R., Pachter, H. L. and Newman, E. (2012), Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma. J. Surg. Oncol., 105: 81–84. doi: 10.1002/jso.22048
- Issue published online: 6 DEC 2011
- Article first published online: 25 JUL 2011
- Manuscript Accepted: 5 JUL 2011
- Manuscript Received: 12 JAN 2011
- intra-operative fluids;
- post-operative morbidity
Excess use of intravenous fluid can increase post-operative complications. We examined the influence of intra-operative crystalloid (IOC) administration on complications following pancreaticodudenectomy (PD) for pancreatic adenocarcinoma.
We categorized 188 patients who underwent PD for adenocarcinoma (1990–2009) into two groups: Group I received <6,000 ml and Group II received ≥6,000 ml IOC. Differences between groups in length of stay, overall morbidity, and 30-day mortality were evaluated.
There were 86 patients in Group I and 102 in Group II. Group I patients were older and with higher percentage of women, but similar in regards to performance status, ASA score, underlying comorbidities, and administration of neo-adjuvant treatment. Group II patients had longer operations, increased blood loss, and higher rates of intra-operative blood transfusions. There were two post-operative deaths, both in the Group II (P = 0.5). Post-operative overall morbidity was 45.7%, without differences between the two groups (44.2% vs. 47.1%, P = 0.7). Likewise, length of post-operative stay was similar in both groups (13.8 days vs. 14.5 days, P = 0.5).
The volume of IOC increased with duration of surgery, intra-operative blood losses, and intra-operative blood transfusion, but did not correlate with post-operative morbidity. J. Surg. Oncol. 2012; 105:81–84. © 2011 Wiley Periodicals, Inc.