Long-term results and prognostic factors of gastric cancer patients with only positive peritoneal lavage cytology

Authors

  • Cheong Ah Oh MD,

    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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  • Jae Moon Bae MD, PhD, FACS,

    Corresponding author
    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    • Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-dong, Gangnam-gu, Seoul 135-710, Korea. Fax: 82-3410-6981
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  • Seung Jong Oh MD,

    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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  • Min Gew Choi MD, PhD,

    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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  • Jae Hyung Noh MD, PhD,

    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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  • Tae Sung Sohn MD, PhD,

    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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  • Sung Kim MD, PhD

    1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
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Abstract

Background and Objectives

The purpose of the present study was to investigate clinicopathologic features of gastric cancer patients with only positive peritoneal cytology in the absence of overt peritoneal metastases, and which might distinguish patients with poorer prognosis.

Methods

Between September 1994 and August 2006, clinicopathological features were retrospectively evaluated in 37 consecutive patients with gastric cancer who underwent a curative resection and had positive peritoneal cytology in the absence of overt peritoneal metastases. Survival including disease-free survival (DFS) and overall survival (OS), and recurrence patterns were analyzed according to clinicopathologic characteristics.

Results

The median follow-up period was 16.1 months (range, 3–45 months). The median DFS and OS of patients after curative resection were 10 months (range, 1–33 months) and 15 months (range, 2–45 months), respectively. All patients had recurred, in 34 (92%) with peritoneal dissemination. The overall 1-, 2-, 3-, and 5-year survival rates for the 37 consecutive patients were 43.2%, 45.9%, 5.4%, and 0%, respectively. Multiple linear regression analysis revealed that Borrmann type IV was an independent predictor for poorer prognosis.

Conclusions

A Borrmann type IV carcinoma may be the candidates for intraperitoneal chemotherapy among advanced gastric cancer patients. J. Surg. Oncol. 2012;105:393–399. © 2011 Wiley Periodicals, Inc.

Ancillary