Post-radiation sarcomas. Clinical outcome of 52 Patients
Version of Record online: 19 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 105, Issue 6, pages 570–576, 1 May 2012
How to Cite
Mavrogenis, A. F., Pala, E., Guerra, G. and Ruggieri, P. (2012), Post-radiation sarcomas. Clinical outcome of 52 Patients. J. Surg. Oncol., 105: 570–576. doi: 10.1002/jso.22122
- Issue online: 9 APR 2012
- Version of Record online: 19 OCT 2011
- Manuscript Accepted: 23 SEP 2011
- Manuscript Received: 8 AUG 2011
- radiation therapy;
- post-radiation bone sarcomas;
- post-radiation soft-tissue sarcomas
Previous studies reported on post-radiation sarcomas. However, the incidence, latency from radiation therapy, treatment, and survival has been difficult to evaluate. We performed a retrospective, single-institutional study to determine these factors for post-radiation sarcomas.
Materials and Methods
We retrospectively studied 52 patients with post-radiation sarcomas diagnosed and treated from 1985 to 2011. The mean age was 49 years; 45 patients had bone and 7 soft tissue sarcoma. The mean follow-up was 45 months. Survival was analyzed with respect to age at diagnosis, type (bone vs. soft tissue), histology, location (trunk vs. extremities), size, and surgical treatment (resection vs. amputation).
The risk of post-radiation sarcoma was 0.06% at a mean latency of 15 years (3–50 years) after radiation therapy. The most common histology was osteosarcoma followed by malignant fibrous histiocytoma and fibrosarcoma; all sarcomas were high grade. Survival of the patients with post-radiation sarcomas was 85% at 1 year, 51% at 2 years, 48% at 3 years, and 45% at 5 years. Univariate predictor of survival was only the type of the sarcoma. No variable was significant in multivariate analysis.
Prognosis of post-radiation sarcomas is poor; the type of the sarcomas is the only significant variable for survival. J. Surg. Oncol. 2012; 105:570–576. © 2011 Wiley Periodicals, Inc.