Elevated high-sensitivity C-reactive protein, a marker of advanced stage gastric cancer and postgastrectomy disease recurrence
Article first published online: 24 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 105, Issue 4, pages 405–409, 15 March 2012
How to Cite
Woo, Y., Hyung, W. J., Obama, K., Kim, H.-I., Pak, K. H., Son, T. and Noh, S. H. (2012), Elevated high-sensitivity C-reactive protein, a marker of advanced stage gastric cancer and postgastrectomy disease recurrence. J. Surg. Oncol., 105: 405–409. doi: 10.1002/jso.22129
- Issue published online: 6 FEB 2012
- Article first published online: 24 OCT 2011
- Manuscript Accepted: 30 SEP 2011
- Manuscript Received: 23 MAY 2011
- Korea Healthcare Technology R&D Project, Ministry of Health, Welfare, & Family Affairs, Republic of Korea. Grant Number: 1020410
- gastric cancer recurrence;
- and biomarker
Background and Objectives
Gastric cancer recurrence after curative surgery remains high. Although no preoperative marker of gastric cancer progression after radical gastrectomy exists, recent studies suggest that C-reactive protein (CRP) is associated with cancer progression. Our study evaluated the significance of preoperative high-sensitivity CRP (hs-CRP) levels as a marker of disease progression after radical gastrectomy.
The preoperative hs-CRP levels of 1,221 gastric cancer patients who underwent radical gastrectomies were analyzed for clinicopathologic significance. Patients with previous gastric cancer treatment, another primary cancer, active infection, or postoperative mortality were excluded.
hs-CRP levels were significantly associated with increased tumor depth (P = 0.028), nodal status (P = 0.012), and stage (P = 0.045). Seventeen percent of patients had elevated hs-CRP levels at the cutoff value of >3.00 mg/L, whereas 6.6% and 6.1% of patients had CEA and CA-19-9 levels about the cutoffs of ≥5.00 ng/ml and ≥35.0 U/L, respectively. Hs-CRP levels >3.00 mg/L were an independent risk factor for recurrence-free survival along with stage.
Elevated preoperative hs-CRP levels in gastric cancer patients are clinically significant indicators of advanced stage and postoperative disease recurrence. J. Surg. Oncol. 2012;105:405–409. © 2011 Wiley Periodicals, Inc.