Conflict of interest: none.
Analysis of p16INK4A expression of oral squamous cell carcinomas in Taiwan: Prognostic correlation without relevance to betel quid consumption†
Version of Record online: 21 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 106, Issue 2, pages 149–154, 1 August 2012
How to Cite
Chen, Y.-W., Kao, S.-Y. and Yang, M.-H. (2012), Analysis of p16INK4A expression of oral squamous cell carcinomas in Taiwan: Prognostic correlation without relevance to betel quid consumption. J. Surg. Oncol., 106: 149–154. doi: 10.1002/jso.23067
- Issue online: 8 JUL 2012
- Version of Record online: 21 FEB 2012
- Manuscript Accepted: 24 JAN 2012
- Manuscript Received: 16 NOV 2011
- National Science Council. Grant Number: NSC-99-2314-B-010-007-MY3
- Department of Health, Center of Excellence for Cancer Research. Grant Number: DOH100-TD-C-111-007
- oral squamous cell carcinoma;
In this study, we examined the role of p16INK4A, a surrogate biomarker of HPV-related head and neck cancers with better prognosis, in an endemic area of betel quid (BQ)-related oral squamous cell carcinoma (OSCC).
p16INK4A immunohistochemistry was examined in 165 OSCCs, statistical analyses were performed to elucidate the correlation between p16INK4A expression and BQ habits/pathologic features, and the prognostic impact of p16INK4A and different parameters were analyzed.
The incidence of p16INK4A expression was similar between BQ chewers and non-chewers. p16INK4A expression was significantly associated with nodal metastasis (P = 0.005). There was a trend suggesting that the loss of p16INK4A expression was more frequent in higher T stages, however, this was found only in patients without lymph node metastasis (P = 0.059). A poorer prognosis and a higher risk of tumor recurrence were found in OSCCs without p16INK4A expression. (The HR for cancer-specific mortality and cancer recurrence was 3.55 and 1.89, respectively.)
Although it has been suggested that BQ chewers had a greater tendency toward tumor recurrence and poor outcome, our data demonstrated that p16INK4A expression is unrelated to BQ habit and that p16INK4A downregulation is a strong predictor for OSCC progression, recurrence and survival in Taiwan. J. Surg. Oncol. 2012; 106:149–154. © 2012 Wiley Periodicals, Inc.