Professor and Chairman.
Management of advanced carcinoma of the base of tongue†
Version of Record online: 24 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 106, Issue 6, pages 713–718, 1 November 2012
How to Cite
Karatzanis, A. D., Psychogios, G., Mantsopoulos, K., Zenk, J., Velegrakis, G. A., Waldfahrer, F. and Iro, H. (2012), Management of advanced carcinoma of the base of tongue. J. Surg. Oncol., 106: 713–718. doi: 10.1002/jso.23135
Alexander D. Karatzanis and Georgios Psychogios contributed equally to this manuscript.
- Issue online: 18 OCT 2012
- Version of Record online: 24 APR 2012
- Manuscript Accepted: 2 APR 2012
- Manuscript Received: 24 DEC 2011
- base of tongue;
- local control;
Background and Objective
Base-of-tongue carcinoma is a relatively rare disease with aggressive behavior and poor prognosis. Up to date no consensus exists regarding the ideal management strategy for each stage of the disease. This study aims to evaluate the experience of a single head and neck oncology center in the management of advanced stage base-of-tongue cancer.
A retrospective evaluation of cases primarily treated for stage III/IVA–B base-of-tongue carcinoma, between 1980 and 2007, at a tertiary referral center.
A total of 366 cases were studied. Five-year disease specific survival (DSS) was 42% and local control (LC) 80%. Regional and distal control estimates were 91.3 and 84%, respectively. Prognosis was significantly superior for cases receiving surgery plus adjuvant treatment compared to cases solely managed with non-surgical modalities. Positive surgical margins and regional disease significantly worsened prognosis. Satisfactory retention of pharyngeal function and no fatal complications were noted in surgical cases.
Although no consensus exists regarding ideal therapy for advanced base-of-tongue carcinoma, combined strategies with the use of surgery and adjuvant chemoradiotherapy (CRT) seem to offer the best possibility for a positive outcome. J. Surg. Oncol. 2012; 106:713–718. © 2012 Wiley Periodicals, Inc.