Pancreatic resection is one part of a multimodal, multidisciplinary approach to current treatment of pancreatic adenocarcinoma. The operation herein has been divided into six discreet steps followed by methods of reconstruction. Management of portal venous and arterial involvement is discussed in detail. The key steps to safe pancreatic surgery are emphasized as one part of present and future pancreatic cancer care. J. Surg. Oncol. 2013;107:33–38. © 2012 Wiley Periodicals, Inc.