A multidisciplinary approach to giant cell tumors of tendon sheath and synovium—A critical appraisal of literature and treatment proposal
Article first published online: 17 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 107, Issue 4, pages 433–445, March 2013
How to Cite
van der Heijden, L., Gibbons, C.L. M. H., Hassan, A. B., Kroep, J. R., Gelderblom, H., van Rijswijk, C. S.P., Nout, R. A., Bradley, K. M., Athanasou, N. A., Dijkstra, P.D. S., Hogendoorn, P. C. W. and van de Sande, M. A. J. (2013), A multidisciplinary approach to giant cell tumors of tendon sheath and synovium—A critical appraisal of literature and treatment proposal. J. Surg. Oncol., 107: 433–445. doi: 10.1002/jso.23220
- Issue published online: 19 FEB 2013
- Article first published online: 17 JUL 2012
- Manuscript Accepted: 19 JUN 2012
- Manuscript Received: 26 JAN 2012
- diffuse type giant cell tumor;
- pigmented villonodular synovitis;
- giant cell tumor of tendon sheath;
- nodular tenosynovitis;
Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular. J. Surg. Oncol. 2013;107:433–445. © 2012 Wiley Periodicals, Inc.