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Keywords:

  • diffuse type giant cell tumor;
  • pigmented villonodular synovitis;
  • giant cell tumor of tendon sheath;
  • nodular tenosynovitis;
  • synovectomy;
  • radiation;
  • isotopes;
  • imatinib

Abstract

Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular. J. Surg. Oncol. 2013;107:433–445. © 2012 Wiley Periodicals, Inc.