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Podoplanin expression in cutaneous head and neck squamous cell carcinoma—prognostic value and clinicopathologic implications

Authors

  • Matthias Kreppel MD, DMD,

    Corresponding author
    1. Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany
    2. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
    • Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Kerpener Strasse 62, 50931 Cologne, Germany. Fax: 49-221-478-7360.===

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  • Anton Krakowezki DMD,

    1. Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany
    2. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
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  • Barbara Kreppel MD,

    1. Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany
    2. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
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  • Uta Drebber MD, PhD,

    1. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
    2. Department of Pathology, University of Cologne, Cologne, Germany
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  • Inga Wedemeyer MD,

    1. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
    2. Department of Pathology, University of Cologne, Cologne, Germany
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  • Cornelia Mauch MD, PhD,

    1. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
    2. Department of Dermatology, University of Cologne, Cologne, Germany
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  • Joachim E. Zöller MD, DMD, PhD,

    1. Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany
    2. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
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  • Martin Scheer MD, DMD, PhD

    1. Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Germany
    2. Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany
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  • There are no financial disclosures from any authors.

Abstract

Background

Although most patients are cured by local treatment from cutaneous head and neck squamous cell carcinoma (cHNSCC), a significant number of patients develops metastases to the regional lymph nodes. Recent studies suggest an influence of podoplanin expression on regional lymph node metastases in other head and neck squamous cell carcinoma. The aim of our study was to assess the impact of podoplanin expression on regional lymph node metastasis, locoregional recurrence, and prognosis.

Methods

In this retrospective study, podoplanin expression was examined immunohistochemically in 63 treatment-naive patients with cHNSCC. We analyzed associations of podoplanin expression and clinicopathologic variables. Furthermore, we investigated the effects on overall survival (OS) and locoregional control in univariate and multivariate analysis.

Results

In 40 patients (63.5%), podoplanin was expressed in the tumor cells. The χ2-test revealed that podoplanin expression was associated with the number of tumorous lymph nodes (P < 0.001). The OS was significantly influenced by podoplanin expression (P < 0.001). None of the patients with high levels of podoplanin expression survived, whereas the 5-year OS for patients with podoplanin-negative tumors was 91.3%.

Conclusions

We concluded that podoplanin is frequently expressed in cHNSCC and might serve as predictor for regional lymph node metastases, locoregional recurrence, and clinical outcome. J. Surg. Oncol. 2013;107:376–383. © 2012 Wiley Periodicals, Inc.

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