Conflicts of interest: none to report.
Prognostic significance of tetraspanin CD151 in newly diagnosed glioblastomas†
Article first published online: 23 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 107, Issue 6, pages 646–652, 1 May 2013
How to Cite
Lee, D., Suh, Y.-L., Park, T.-I., Do, I.-G., Seol, H. J., Nam, D.-H. and Kim, S. T. (2013), Prognostic significance of tetraspanin CD151 in newly diagnosed glioblastomas. J. Surg. Oncol., 107: 646–652. doi: 10.1002/jso.23249
- Issue published online: 16 APR 2013
- Article first published online: 23 AUG 2012
- Manuscript Accepted: 1 AUG 2012
- Manuscript Received: 15 FEB 2012
- O6-methylguanin-DNA methyltransferase;
Tetraspanin CD151 is a positive effector of cancer invasion and metastasis.
We investigated the expression of CD151 by immunohistochemistry in 211 cases of grade I to IV gliomas. Additionally, we performed O6-methylguanin-DNA methyltransferase (MGMT) methylation analysis using real-time methylation-specific PCR in 36 patients with glioblastoma, and the prognostic significance of these biomarkers in glioblastomas was evaluated.
Overexpression of CD151 was observed in a significant proportion (55.6%) of glioblastomas, while CD151 was rarely overexpressed in most of grade I to III glial tumors. CD151 overexpression was closely associated with MGMT methylation (P = 0.014), and it was a prognostic factor for predicting worse overall survival (OS; P = 0.002) and progression-free survival (PFS; P = 0.043). We also found that combination of CD151 overexpression and MGMT methylation better stratified the patients' OS (P = 0.001) and PFS (P = 0.009). In multivariate analysis, CD151 overexpression was an independent prognostic factor for predicting OS over MGMT methylation (P = 0.012).
CD151 seems to have a critical role for high-grade progression in astroglial tumors. Furthermore, CD151 is a good tissue marker that can be used easily in a daily practice for predicting worse prognosis in patients with glioblastoma. J. Surg. Oncol. 2013;107:646–652. © 2012 Wiley Periodicals, Inc.