The authors do not have any financial interests or conflicts of interest to disclose, and this work was not funded in any way.
Version of Record online: 20 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 107, Issue 4, pages 324–328, 15 March 2013
How to Cite
Kennedy, T. J., Cassera, M. A., Khajanchee, Y. S., Diwan, T. S., Hammill, C. W. and Hansen, P. D. (2013), Laparoscopic radiofrequency ablation for the management of colorectal liver metastases: 10-year experience. J. Surg. Oncol., 107: 324–328. doi: 10.1002/jso.23268
Material from this article was presented at the Society of Surgical Oncology 64th Annual Cancer Symposium, San Antonio, TX. March 2–5, 2011.
- Issue online: 19 FEB 2013
- Version of Record online: 20 SEP 2012
- Manuscript Accepted: 27 AUG 2012
- Manuscript Received: 20 FEB 2012
- colorectal cancer;
- liver metastases;
- radiofrequency ablation;
- hepatic ablation
Published results addressing the treatment of colorectal liver metastases (CRLM) with radiofrequency ablation (RFA) vary widely with local recurrence rates of 2–40% and 5-year survival of 14–55%. The goal of this study was to analyze our 10-year experience with laparoscopic RFA.
From January 2000 to July 2010, 130 patients underwent laparoscopic RFA for CRLM. Kaplan–Meier analysis was used to assess survival. Univariate and multivariate analysis were performed to identify factors associated with survival and recurrence.
In this cohort, median survival was 40.4 months with 5-year survival of 28.8%. Overall, 9.2% of patients had a local recurrence (3.6% for tumors 3 cm or less). On univariate analysis, factors associated with decreased survival were BMI (P = 0.045), rectal primary (P = 0.005), and increased tumor size (P = 0.002). On multivariate analysis, increased tumor size (HR 1.29 [95% CI: 1.04–1.59]; P = 0.020) and bilobar disease (HR 2.06 [95% CI: 1.02–4.15]; P = 0.044) were associated with decreased survival. On univariate analysis, only BMI was found to be associated with disease recurrence (P = 0.025).
Our data demonstrate that laparoscopic RFA can achieve a median survival of 40.4 months with a low local recurrence rate. Patients with tumors 3 cm or less have a decreased risk of local recurrence. J. Surg. Oncol. 2013;107:324–328. © 2012 Wiley Periodicals, Inc.