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Laparoscopic radiofrequency ablation for the management of colorectal liver metastases: 10-year experience

Authors

  • Timothy J. Kennedy MD,

    1. Department of Surgery, Montefiore Medical Center, New York City, New York
    2. Hepatobiliary and Pancreatic Surgery Program, Providence Portland Medical Center, Portland, Oregon
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  • Maria A. Cassera BS,

    1. Hepatobiliary and Pancreatic Surgery Program, Providence Portland Medical Center, Portland, Oregon
    2. Gastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, Oregon
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  • Yashodhan S. Khajanchee MD,

    1. Hepatobiliary and Pancreatic Surgery Program, Providence Portland Medical Center, Portland, Oregon
    2. Gastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, Oregon
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  • Tayyab S. Diwan MD,

    1. Hepatobiliary and Pancreatic Surgery Program, Providence Portland Medical Center, Portland, Oregon
    2. Gastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, Oregon
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  • Chet W. Hammill MD, MS,

    1. Hepatobiliary and Pancreatic Surgery Program, Providence Portland Medical Center, Portland, Oregon
    2. Gastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, Oregon
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  • Paul D. Hansen MD

    Corresponding author
    1. Hepatobiliary and Pancreatic Surgery Program, Providence Portland Medical Center, Portland, Oregon
    2. Gastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, Oregon
    • Director, Hepatobiliary and Pancreatic Surgery Program Providence Portland Medical Center, 4805 NE Glisan Street, Suite 6N50, Portland, OR 97213. Fax: +1-503-416-7377.===

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  • The authors do not have any financial interests or conflicts of interest to disclose, and this work was not funded in any way.

  • Material from this article was presented at the Society of Surgical Oncology 64th Annual Cancer Symposium, San Antonio, TX. March 2–5, 2011.

Abstract

Background

Published results addressing the treatment of colorectal liver metastases (CRLM) with radiofrequency ablation (RFA) vary widely with local recurrence rates of 2–40% and 5-year survival of 14–55%. The goal of this study was to analyze our 10-year experience with laparoscopic RFA.

Methods

From January 2000 to July 2010, 130 patients underwent laparoscopic RFA for CRLM. Kaplan–Meier analysis was used to assess survival. Univariate and multivariate analysis were performed to identify factors associated with survival and recurrence.

Results

In this cohort, median survival was 40.4 months with 5-year survival of 28.8%. Overall, 9.2% of patients had a local recurrence (3.6% for tumors 3 cm or less). On univariate analysis, factors associated with decreased survival were BMI (P = 0.045), rectal primary (P = 0.005), and increased tumor size (P = 0.002). On multivariate analysis, increased tumor size (HR 1.29 [95% CI: 1.04–1.59]; P = 0.020) and bilobar disease (HR 2.06 [95% CI: 1.02–4.15]; P = 0.044) were associated with decreased survival. On univariate analysis, only BMI was found to be associated with disease recurrence (P = 0.025).

Conclusions

Our data demonstrate that laparoscopic RFA can achieve a median survival of 40.4 months with a low local recurrence rate. Patients with tumors 3 cm or less have a decreased risk of local recurrence. J. Surg. Oncol. 2013;107:324–328. © 2012 Wiley Periodicals, Inc.

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