Authors have no financial disclosures.
Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma†
Article first published online: 28 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 107, Issue 6, pages 634–640, 1 May 2013
How to Cite
Strong, V. E., Song, K. Y., Park, C. H., Jacks, L. M., Gonen, M., Shah, M. A., Coit, D. G. and Brennan, M. F. (2013), Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma. J. Surg. Oncol., 107: 634–640. doi: 10.1002/jso.23288
- Issue published online: 16 APR 2013
- Article first published online: 28 NOV 2012
- Manuscript Accepted: 15 OCT 2012
- Manuscript Received: 2 JUL 2012
- gastric carcinoma;
- early gastric cancer;
- Eastern and Western
Background and Objectives
Disease-specific survival (DSS) for GC patients differs in Eastern and Western countries. The aim is to compare outcomes of US and Korean patients following resection of early-stage, node-negative gastric carcinoma (GC).
All patients (1995–2005) with T1N0 gastric carcinoma, excluding gastroesophageal tumors, were evaluated. DSS was compared by adjusting for prognostic variables from an internationally validated GC nomogram.
The cohort included 598 Korean patients and 159 US patients. Age and BMI were significantly higher in US patients. Distal tumor location was more frequent in Korea (60% vs. 52%) and proximal location in the US (19% vs. 5%, P < 0.0001). Five-year DSS did not differ significantly between Korea and the US. After multivariate analysis, DSS of Korean patients persisted, with no significant differences when compared to US patients (HR = 1.2, 95% CI: 0.3–5.2, P = 0.83).
Despite widespread speculations that GC differs in the East and West, when we compare similarly staged, node-negative GC patients, survival did not differ significantly between Korea and the US. This suggests that GC is a heterogeneous disease and when similar subtypes of gastric cancer are compared, these differences disappear. This study suggests more similarities than previously hypothesized between US and Korean GC patients. J. Surg. Oncol. 2013;107:634–640. © 2012 Wiley Periodicals, Inc.