Tumor-positive resection margins reflect an aggressive tumor biology in pancreatic cancer

Authors

  • Charles W. Kimbrough MD,

    1. Division of Surgical Oncology, The Hiram C. Polk, J.R., M.D. Department of Surgery, University of Louisville, Louisville, Kentucky
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  • Charles R. St. Hill MD, MSc,

    1. Division of Surgical Oncology, The Hiram C. Polk, J.R., M.D. Department of Surgery, University of Louisville, Louisville, Kentucky
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  • Robert C.G. Martin MD, PhD,

    1. Division of Surgical Oncology, The Hiram C. Polk, J.R., M.D. Department of Surgery, University of Louisville, Louisville, Kentucky
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  • Kelly M. McMasters MD, PhD,

    1. Division of Surgical Oncology, The Hiram C. Polk, J.R., M.D. Department of Surgery, University of Louisville, Louisville, Kentucky
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  • Charles R. Scoggins MD, MBA

    Corresponding author
    1. Division of Surgical Oncology, The Hiram C. Polk, J.R., M.D. Department of Surgery, University of Louisville, Louisville, Kentucky
    • The Hiram C. Polk, J.R., M.D. Department of Surgery, University of Louisville, 315 E. Broadway, Suite 303, Louisville, KY 40202. Fax: 502-629-3030.===

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Abstract

Background

Resection margin status has been shown to impact outcomes for pancreatic adenocarcinoma (PAC), yet it remains unknown whether margin status is a reflection of tumor biology or surgical technique.

Methods

Two hundred eighty-three consecutive patients with pancreatic adenocarcinoma were identified in a prospectively maintained database. Only patients with R0 (n = 207) or R1 (n = 76) tumors were included. Each operative surgeon's first 50 cases were excluded to control for technical inexperience. Univariable and multivariable analyses of clinicopathologic and intra-operative factors were performed.

Results

The median follow-up for the cohort was 30.3 months with a median overall survival (OS) of 19.0 months. The R1 group had a higher rate of lymph node ratio >0.2 (41% vs. 25%; P = 0.013), and more microvascular invasion (64% vs. 44%; P = 0.007). R0 resections had both improved overall survival (22.7 months vs. 15.0 months, P = 0.004) and disease free survival (13.5 months vs. 10.7 months, P = 0.026). Factors independently associated with overall survival were microvascular invasion (HR 2.26; P = 0.001), pre-existing pulmonary disease (HR 2.18, P = 0.043), and cardiac disease (HR 1.78, P = 0.033).

Conclusion

Factors associated with an R1 resection reflect a biologically more aggressive tumor, with a higher likelihood of microvascular invasion and increased positive lymph node ratio. J. Surg. Oncol. 2013;107:602–607. © 2013 Wiley Periodicals, Inc.

Ancillary