Matrix metalloproteinase-12 is associated with overall survival in Chinese patients with gastric cancer

Authors

  • Jianyong Zheng,

    Corresponding author
    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    • Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China. Fax: +86-29-84771527.===

    Search for more papers by this author
  • Dake Chu,

    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Desheng Wang,

    1. Department of General Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Yongsheng Zhu,

    1. UItrasonic Diagnosis Deparment, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Xiaoyin Zhang,

    1. Digestive System Department, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Gang Ji,

    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Haihong Zhao,

    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Guosheng Wu,

    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Jianjun Du,

    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author
  • Qingchuan Zhao

    1. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
    Search for more papers by this author

  • Jianyong Zheng, Dake Chu, Dengsheng Wang, and Yongsheng Zhu contributed equally to this work.

Abstract

Background and Objectives

Matrix metalloproteinase-12 (MMP-12) plays an important role in invasion and metastasis of human solid tumor cells. This study aimed to investigate the association of MMP-12 with overall survival in human gastric cancer.

Methods

Gastric cancer and adjacent normal tissue specimens were collected from 165 patients who had not received neoadjuvant chemotherapy. MMP-12 expression was determined by immunohistochemical staining, and the results were analyzed statistically in relation to the overall survival of the patients.

Results

MMP-12 expression was increased in gastric cancer compared with that observed in normal tissues. Increased MMP-12 expression was associated with tumor invasion, lymph node metastasis, distant metastasis, and TNM stage. No correlations were detected between MMP-12 expression and age, sex, differentiation status, tumor site, or Lauren classification. Moreover, patients with MMP-12 positive gastric cancer tended to have worse overall survival compared with those patients without MMP-12 expression.

Conclusions

The study results showed that increased expression of MMP-12 was associated with tumor progression in gastric cancer. It also provided the first evidence for MMP-12 expression in gastric cancer as an independent prognostic factor. J. Surg. Oncol. 2013;107:746–751. © 2012 Wiley Periodicals, Inc.

Ancillary