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Management of primary hepatopancreatobiliary small cell carcinoma†
Article first published online: 27 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 107, Issue 7, pages 692–695, 1 June 2013
How to Cite
Groeschl, R. T., Christians, K. K., Turaga, K. K. and Gamblin, T. C. (2013), Management of primary hepatopancreatobiliary small cell carcinoma. J. Surg. Oncol., 107: 692–695. doi: 10.1002/jso.23305
- Issue published online: 25 MAY 2013
- Article first published online: 27 DEC 2012
- Manuscript Accepted: 19 NOV 2012
- Manuscript Received: 4 SEP 2012
- small cell carcinoma;
- oat cell carcinoma;
- bile ducts
Background and Objectives
Primary small cell carcinomas (SCC) of the pancreas, liver, gallbladder, and bile ducts have only been described in case reports. We hypothesized that surgical treatment was associated with improved overall survival (OS) for patients with localized hepatopancreatobiliary SCC.
The Surveillance, Epidemiology, and End-Results (SEER) database was queried for patients with SCC from 1998 to 2008. Survival was analyzed with Cox proportional hazards models.
Eighty-five patients had nonmetastatic hepatopancreatobiliary SCC and operative treatment data. Hepatic SCC was associated with a 2 month median OS, and no patient underwent surgery. Stage-adjusted median OS for pancreatobiliary SCC patients undergoing resection (19 months, 95% confidence interval [CI]: 10–42 months) was greater than those who were not resected (8 months, 95% CI: 4–12 months, P = 0.0052). Both surgical resection (hazard ratio [HR]: 0.42, 95% CI: 0.29–0.63, P < 0.001) and administration of radiation therapy (HR: 0.50, 95% CI: 0.35–0.71, P < 0.001) independently predicted prolonged OS in adjusted models.
Surgical resection was associated with prolonged survival for patients with localized pancreatic, gallbladder, and biliary primaries. While we recognize several biases inherent in a population-based study, these results provide insight into the survival that can be achieved with surgical resection of SCC in these specific locations. J. Surg. Oncol. 2013;107:692–695. © 2012 Wiley Periodicals, Inc.