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Increasing incidence and survival of a rare skin cancer in the Netherlands. A population-based study of 2,220 cases of skin adnexal carcinoma

Authors

  • Hanneke Stam MD,

    1. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
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  • Peter J.F.M. Lohuis MD, PhD,

    1. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
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  • Biljana Zupan-Kajcovski MD,

    1. Department of Dermatology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
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  • Michel W.J.M. Wouters MD,

    1. Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
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  • Jos A. van der Hage MD, PhD,

    1. Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
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  • Otto Visser MD, PhD

    Corresponding author
    1. Comprehensive Cancer Centre The Netherlands, Utrecht, The Netherlands
    • Comprehensive Cancer Centre The Netherlands, PO Box 19079, 3501 DB Utrecht, The Netherlands. Fax: +31-20-3462-525.

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Abstract

Backgrounds and Objectives

The aim of this study was to describe the epidemiology and treatment of skin adnexal carcinoma (SAC) in the Netherlands and to identify prognostic factors for survival in patients with SAC.

Methods

We used population-based nationwide data from the Netherlands Cancer Registry with cases diagnosed during 1989–2010 and followed up to February 1st, 2012.

Results

A total of 2,220 SACs were diagnosed during 1989–2010 (age-standardized incidence rate 5.3 per million). Incidence increased by 2.7% and 1.7% annually in males and females, respectively. Fifteen different morphological types were registered. The 5-year relative survival rate increased from 80% in 1989–1994 to 91% in 2006–2010. The majority of all patients (91%) received surgery. Adjuvant radiotherapy and/or lymph node dissection was performed in only a minority of cases. The risk of death was significantly higher in patients who did not receive surgery.

Conclusions

The rising incidence of SAC together with the predilection for the head and neck region suggests a role for UV radiation in the carcinogenesis of SAC. Furthermore, we found an improved survival of SAC in the Netherlands between 1989 and 2010. In view of the low proportion of patients receiving adjuvant therapy there may be further room for improving survival. J. Surg. Oncol. 2013;107:822–827. © 2013 Wiley Periodicals, Inc.

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