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Screening for lung cancer: The US studies

Authors

  • David E. Midthun MD,

    Corresponding author
    1. Mayo Clinic, Rochester, Minnesota
    • Correspondence to: David E. Midthun, MD, Professor of Medicine, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905. Fax: 507-266-4372.

      E-mail: midthun.david@mayo.edu

      Correspondence to: James R. Jett, MD, Professor of Medicine, National Jewish Health J229, 1400 Jackson St., Denver, Colorado 80206. Fax: 303-398-1476.

      E-mail: jettj@njhealth.org

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  • James R. Jett MD

    Corresponding author
    1. National Jewish Health J229, Denver, Colorado
    • Correspondence to: David E. Midthun, MD, Professor of Medicine, Mayo Clinic, 200 1st Street SW, Rochester, Minnesota 55905. Fax: 507-266-4372.

      E-mail: midthun.david@mayo.edu

      Correspondence to: James R. Jett, MD, Professor of Medicine, National Jewish Health J229, 1400 Jackson St., Denver, Colorado 80206. Fax: 303-398-1476.

      E-mail: jettj@njhealth.org

    Search for more papers by this author

  • Disclosures: D.E.M. has research funding from Integrated Diagnostics (blood biomarkers), J.R.J. has research funding from Oncimmune (blood biomarkers) and Metabolomx (breath analysis) and is on the Advisory Boards for Varian Medical Systems and Quest Diagnostics.

Abstract

Efforts in lung cancer screening with chest X-ray (CXR) and sputum cytology in the 1970s and 1980s were negative. In the ensuing decade, the early lung cancer action project (ELCAP), and the Mayo screening study showed the promise of low-dose CT. These and other studies led to the National lung screening study (NLST), which showed definitively that low-dose spiral computed tomography had a measurable impact on mortality and could be justified as a tool for lung cancer screening. This review examines the results of past and recent studies of lung cancer screening. J. Surg. Oncol. 2013 108:275–279. © 2013 Wiley Periodicals, Inc.

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