Neutrophil-to-lymphocyte ratio as a predictor of outcomes for patients with hepatocellular carcinoma: A Western perspective
Article first published online: 4 OCT 2013
© 2013 Wiley Periodicals, Inc.
Journal of Surgical Oncology
Volume 109, Issue 2, pages 95–97, February 1, 2014
How to Cite
Sullivan, K. M., Groeschl, R. T., Turaga, K. K., Tsai, S., Christians, K. K., White, S. B., Rilling, W. S., Pilgrim, C. H.C. and Gamblin, T. C. (2014), Neutrophil-to-lymphocyte ratio as a predictor of outcomes for patients with hepatocellular carcinoma: A Western perspective. J. Surg. Oncol., 109: 95–97. doi: 10.1002/jso.23448
- Issue published online: 21 JAN 2014
- Article first published online: 4 OCT 2013
- Manuscript Accepted: 10 SEP 2013
- Manuscript Received: 8 SEP 2013
- neutrophil-to-lymphocyte ratio;
- hepatocellular carcinoma;
Background and Objectives
Neutrophil-to-lymphocyte ratio (NLR) is simple, inexpensive, and has been proposed to be predictive in hepatocellular carcinoma (HCC) in Europe and Asia. We aimed to evaluate whether NLR at presentation in a Western center provides any prognostic value compared to other common prognostic scores.
NLR was calculated for 75 consecutive patients at presentation with HCC and regression models were used to analyze its value for predicting treatment strategy and short-term survival with Child-Pugh and Model for End Stage Liver Disease (MELD).
NLR was not predictive of future treatment regimens with hepatectomy, liver transplant, or transarterial chemoembolization (TACE; odds ratio [OR]: 0.85, 95% confidence interval [CI]: 0.71–1.02, P = 0.079) as compared the predictive value of MELD (OR: 0.81, CI: 0.72–0.93, P = 0.002) or Child-Pugh (OR: 0.48, CI: 0.34–0.69, P < 0.001). Adding additional adjustment for treatment, NLR did not correlate with short-term overall survival (hazard ratio [HR]: 1.09, CI: 0.95–1.24, P = 0.227). MELD also did not correlate with overall survival (HR: 1.04, CI: 0.96–1.13, P = 0.357) whereas Child-Pugh (HR: 1.56, CI: 1.10–2.19, P = 0.011) was predictive.
This study does not support the prognostic value of NLR to guide therapy for HCC in a Western center, whereas MELD and Child-Pugh score were more predictive. J. Surg. Oncol. 2014 109:95–97. © 2013 Wiley Periodicals, Inc.