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Keywords:

  • HIPEC;
  • animal experimentation;
  • cytoreductive surgery;
  • colorectal carcinoma;
  • peritoneal metastasis

Abstract

The development of suitable animal models is essential to experimental research on intraperitoneal chemotherapy (IPC). This review of the English literature (MEDLINE) presents a detailed analysis of current animal models and gives recommendations for future experimental research. Special consideration should be given to cytotoxic drug dose and concentration, tumor models, and outcome parameters. J. Surg. Oncol. 2014 109:110–116. © 2013 Wiley Periodicals, Inc.