Chemical and hematological screening in patients with malignant and non-malignant conditions

Authors

  • Dr. Yeu-Tsu N. Lee MD,

    Corresponding author
    1. Departments of Surgery and Biomathematics, Ellis Fischel State Cancer Hospital and Cancer Research Center, and the Missouri Regional Medical Program, Columbia, Missouri, 65201
    Current affiliation:
    1. Department of Surgery, School of Medicine, University of Southern California, Los Angeles, CA 90033
    • Department of Surgery, School of Medicine, University of Southern California, Los Angeles, CA 90033
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  • Hubert J. Van Peenen MD,

    1. Departments of Surgery and Biomathematics, Ellis Fischel State Cancer Hospital and Cancer Research Center, and the Missouri Regional Medical Program, Columbia, Missouri, 65201
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  • Francis R. Watson PhD

    1. Departments of Surgery and Biomathematics, Ellis Fischel State Cancer Hospital and Cancer Research Center, and the Missouri Regional Medical Program, Columbia, Missouri, 65201
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Abstract

The value of multiphasic automated laboratory tests in differentiating stages of malignancy and in detecting recurrence of cancer was studied. Chemical SMA-12 tests (including calcium, phosphate, glucose, BUN, uric acid, cholesterol, total protein, albumin, total bilirubin, alkaline phosphatase (AP), lactic dehydrogenase (LDH) and SGOT) and hematological SMA-4 tests (including hematocrit, hemoglobin, WBC and RBC counts) were performed in 1,578 patients. Baseline data obtained from 582 patients with benign, and 996 patients with malignant, lesions were subdivided according to age, sex, primary site, and extent of cancer. With advancing stages of cancer, there was a significant increase of AP and LDH, but decrease of albumin and hemoglobin. Among patients who had sequential tests, there was a significant decrease of uric acid and LDH with control of cancer, and increase of AP with development of distant dissemination.

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