Immune status in advanced upper gastrointestinal cancers

Authors

  • Gurpreet Singh MS,

    1. Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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  • S. N. Das Ph.D,

    1. Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
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  • Prof. N. N. Khanna MS, FAMS

    Corresponding author
    1. Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    • Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India
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Abstract

Thirty-eight cases of advanced upper gastrointestinal cancer were assessed for their immune status prior to any form of therapy. Cell-mediated immunity, as tested by absolute lymphocyte count, T-cell count and delayed cutaneous hypersensitivity reactions to purified protein derivative and phytohemagglutinin showed severe depression. Immunoglobulins A and M were elevated, while immunoglobulin G reduced. No correlation could be established between the immune status and the site of cancer or its extent, the performance status of the patients, or their response to chemotherapy.

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