Epstein-barr virus related lymphoepithelioma-like carcinoma of lung

Authors

  • Dr. Louis R. Bégin MD,

    Corresponding author
    1. Departments of Pathology and Oncology, McGill University, and The Sir Mortimer B. Davis-Jewish General Hospital, and the Department of Microbiology, Hǒpital Ste-Justine, Montreal, Quebec, Canada
    • Department of Pathology, The Sir Mortimer B, Davis-Jewish General Hospital, 3755 Cǒte Ste-Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Search for more papers by this author
  • Jan Eskandari MD,

    1. Departments of Pathology and Oncology, McGill University, and The Sir Mortimer B. Davis-Jewish General Hospital, and the Department of Microbiology, Hǒpital Ste-Justine, Montreal, Quebec, Canada
    Search for more papers by this author
  • Jean Joncas MD,

    1. Departments of Pathology and Oncology, McGill University, and The Sir Mortimer B. Davis-Jewish General Hospital, and the Department of Microbiology, Hǒpital Ste-Justine, Montreal, Quebec, Canada
    Search for more papers by this author
  • Lawrence Panasci MD

    1. Departments of Pathology and Oncology, McGill University, and The Sir Mortimer B. Davis-Jewish General Hospital, and the Department of Microbiology, Hǒpital Ste-Justine, Montreal, Quebec, Canada
    Search for more papers by this author

Abstract

A malignant neoplasm localized to the lung is reported in a rather unusual host: a 40-year-old female, nonsmoker, of South-East Asiatic origin. The histology was of nasopharyngeal-like carcinoma character and ultrastructural examination confirmed a diagnosis of nonkeratinizing, poorly differentiated squamous cell carcinoma. The clinicopathologic findings were more suggestive of a primary pulmonary origin than the manifestation of an occult nasopharyngeal primary. The immunological profile was highly suggestive of an Epstein-Barr virus (EBV) associated epithelial neoplasia. This case might widen the spectrum of EBV-associated neoplasia, by inclusion of lower respiratory tract as a target organ.

Ancillary