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Article
Complications of hypogastric artery cisplatin infusions
Article first published online: 20 JUL 2006
DOI: 10.1002/jso.2930410306
Copyright © 1989 Wiley-Liss, Inc., A Wiley Company
1096-9098/asset/cover.gif?v=1&s=96beda43b18df3cd9e0fc6722e6240cd02a846a1 "Journal of Surgical Oncology")
Additional Information
How to Cite
Menashe, D. S. and Jacobs, S. C. (1989), Complications of hypogastric artery cisplatin infusions. J. Surg. Oncol., 41: 160–164. doi: 10.1002/jso.2930410306
Publication History
- Issue published online: 20 JUL 2006
- Article first published online: 20 JUL 2006
- Manuscript Accepted: 18 JAN 1989
- Abstract
- References
- Cited By
Keywords:
- intra-arterial;
- bladder cancer;
- neuropathy
Abstract
In an attempt to increase the therapeutic index of Cisplatin (CDDP), 29 continuous 48 hour intra-arterial (IA) infusions of 100–150 mg/m2 CDDP were given to 26 patients with bulky stage T3–T4 bladder cancer. Hypogastric artery catheters were placed distal (n = 42) or proximal (n = 7) to the origin of the superior gluteal artery. Atherosclerosis (n = 5) or aneurysm (n = 2) prevented successful IA catheter placement. Catheter maintenance resulted in no bleeding or thromboembolic episodes. Urethral catheters caused two urinary tract infections. Systemic toxicity was mild with on 4/29 infusions resulting in WBC< 3,000, 3/29 infusions resulting in creatinine elevation, and 1/29 in peripheral neuropathy. Local effects of the IA CDDP included gluteal pain and ecchymosis (n = 1) and moderately disabling lower extremity neuropathies (n = 3). Systemic side effects of CDDP can be diminished by use of IA route of administration and slow continuous infusion.