A simplified approach to direct solid-phase extraction: mass spectrometry
Esme Candish, Andrew Gooley, Hans-Jürgen Wirth, Peter A. Dawes, Robert A. Shellie and Emily F. Hilder
Version of Record online: 19 SEP 2012 | DOI: 10.1002/jssc.201270141
A hand held digital format of the microextraction by packed sorbent technique (MEPS) has been integrated into the ESI-MS workflow for the rapid screening of drugmetabolites in urine. This at-line approach to sample preparation couples rapid workflows with direct analysis enabling the entire analytical workflow to be achieved in a few minutes. A novel format of MEPS has been introduced which incorporates a two-way valve between the MEPS cartridge and the syringe barrel enabling the direction of the flow to be controlled. By controlling the direction of the flow, sharp concentrated sample bands can be introduced directly into the MS in small volumes.