Inverse colloidal crystal membranes for hydrophobic interaction membrane chromatography
Anh T. Vu, Xinying Wang, S. Ranil Wickramasinghe, Bing Yu, Hua Yuan, Hailin Cong, Yongli Luo and Jianguo Tang
Article first published online: 18 AUG 2015 | DOI: 10.1002/jssc.201570161
J. Sep. Sci. 2015, 38, 2819–2825
Cover picture illustrates a novel procedure for the preparation of inverse colloidal crystal (ICC) membranes of polyhydroxybutyl methacrylate based copolymers using silica colloidal crystals as templates. The ICC membranes have uniform pores, high porosity and therefore surface area for protein binding, are used as hydrophobic interaction membrane chromatography membranes for humanized monoclonal antibody immunoglobulin G purification. The capacity of the ICC membranes is up to 10 times greater than commercially available polyvinylidene fluoride membranes with a similar pore size.