The purpose of this study was to test the direct and moderating effects of job strain variables on the Job Demand–Control–Support model. A total of 422 tourism employees completed a questionnaire. Hierarchical and moderated regression models were employed to test the proposed relationships between job strain variables and work-to-leisure conflict. Results indicated that job demands had a positive relationship with work-to-leisure conflict, whereas the schedule flexibility and the time-off flexibility were negatively related to work-to-leisure conflict. Results also found that supervisor support could moderate the influence of tourism employees' job demands on work-to-leisure conflict. Implications of stress management and job design for human resource department are discussed. Copyright © 2013 John Wiley & Sons, Ltd.