Trace element levels in the experimental peritonitis
Article first published online: 29 APR 2002
Copyright © 2002 Wiley-Liss, Inc.
The Journal of Trace Elements in Experimental Medicine
Volume 15, Issue 2, pages 79–84, 2002
How to Cite
Konukoğlu, D., Ercan, M. and Ziylan, E. (2002), Trace element levels in the experimental peritonitis. J. Trace Elem. Exp. Med., 15: 79–84. doi: 10.1002/jtra.10006
- Issue published online: 29 APR 2002
- Article first published online: 29 APR 2002
- Manuscript Accepted: 4 OCT 2000
- Manuscript Received: 1 JAN 2000
- lipid peroxidation;
Electron transfer from iron or copper ions to oxygen is an important example of cellular free radical initiation. Oxygen-derived free radicals have been implicated as mediators of cellular injury in several model systems. To evaluate the importance of iron, copper, and zinc levels on lipid peroxidation in peritonitis, we measured peritoneum malondialdehyde (MDA) as a marker of lipid peroxidation, zinc, copper, and iron levels during an animal model of intraperitoneal sepsis. Additionally, the effects of free radical scavenger alpha-tocopherol administration were studied. The peritoneum MDA, iron, copper, and zinc levels were increased after induction of peritonitis with Escherichia coli. The treatment with alpha-tocopherol decreased peritoneum MDA, iron, and copper levels significantly but not the zinc levels. Additionally, the treatment with alpha-tocopherol 3 days prior to injection of E. coli decreased MDA, copper, and iron levels more than treatment with alpha-tocopherol at the time of injection of E. coli. Our results indicate that copper, iron, and zinc have important effects on peroxidation events in E. coli-induced peritonitis and that alpha-tocopherol treatment can improve the oxidant status. J. Trace Elem. Exp. Med. 15:79–84, 2002. © 2002 Wiley-Liss, Inc.