Disorders in blood coagulation in humans occupationally exposed to mercuric vapors
Article first published online: 18 JAN 2002
Copyright © 2002 Wiley-Liss, Inc.
The Journal of Trace Elements in Experimental Medicine
Volume 15, Issue 1, pages 21–29, 2002
How to Cite
Wierzbicki, R., Prażanowski, M., Michalska, M., Krajewska, U. and Mielicki, W. P. (2002), Disorders in blood coagulation in humans occupationally exposed to mercuric vapors. J. Trace Elem. Exp. Med., 15: 21–29. doi: 10.1002/jtra.1055
- Issue published online: 18 JAN 2002
- Article first published online: 18 JAN 2002
- Manuscript Accepted: 15 MAR 2001
- Manuscript Received: 2 JUN 2000
- blood clotting;
Changes in blood coagulation system were studied in humans that were occupationally exposed to mercuric vapors. The following parameters were analyzed: mercury concentration in plasma, thrombin generation, thrombin-antithrombin complexes, soluble fibrin monomers, factor XIII, protein C, platelet factor 4, and β-thromboglobulin. There was statistically significant increase in the activity of factor XIII, concentration of platelet factor 4 and thrombin generation in plasma of workers exposed to mercuric vapors as compared with unexposed controls. There was also an increase in thrombin-antithrombin complexes and β-thromboglobulin concentration accompanied by a decrease in protein C activity in the workers exposed to mercury. However, the last differences were not statistically significant. The data suggest that in humans exposed to mercuric vapors the hemostatic balance is shifted on the hypercoagulative side. J. Trace Elem. Exp. Med. 15:21–29, 2002. © 2002 Wiley-Liss, Inc.