The 5-HTTLPR Polymorphism and Posttraumatic Stress Disorder: A Meta-Analysis


  • We express our gratitude to Iris-Tatjana Kolassa and Stephan Kolassa, who shared their data with us, and to Hans Jorgen Grabe for his help.


Environmental and genetic factors contribute to the development of posttraumatic stress disorder (PTSD). Variation in the 5-HTTLPR polymorphism of the serotonin transporter gene has been hypothesized to affect risk for PTSD. With the aim of investigating this association, we conducted a meta-analysis to shed light on prior controversial results and increase statistical power to detect smaller effect sizes. PubMed and ISI databases were searched for studies published until December 2012. Twelve studies have been included, all based on trauma-exposed samples. Data were analyzed with Cochrane Collaboration Review Manager Software (Version 5). Quality and publication bias were assessed. Metaregressions were performed using Comprehensive Meta-Analysis software, Version 2. Taking into account all studies, no association was found between 5-HTTLPR and PTSD (p = .10), with evidence of between-study heterogeneity, which could be partly explained by gender differences. In sensitivity analyses, we found an association between SS genotype and PTSD in high trauma-exposed participants (p < .001). To be a carrier of the SS genotype seems to represent a risk factor for PTSD in high trauma exposure. Further studies focusing on Gene × Environment interactions are needed to better understand the role of this polymorphism in PTSD.

Traditional and Simplified Chinese Abstracts by AsianSTSS


撮要:創傷後壓力症(PTSD)的形成有其環境和基因因素,其中5-HTTLPR多態性變異是一項假設性風險因素。我們使用元分析研究其中關連來顯示昔日具爭議性結果的情況,和增強統計學效能以查找較小效應值。我們找尋所有Pub Med和ISI資料庫內的研究,但不包括2012年12月後的研究。發掘了共12項使用經歷創傷樣本的研究,再利用Cochrane協力回顧處理軟件第五版來分析及評核其中品質和出版偏差,後使用綜合元分析軟件來整理元回歸。綜合上述所有研究,5-HTTLPR和PTSD並無關連(p = .10),但研究之間並不均一,而部份不均一性是由於性別差異。使用敏感性分析,嚴重創傷經歷人士中SS基因型與PTSD有相連(p<.001),即SS基因型載體是嚴重創傷經歷中PTSD的風險因素。我們必須加強研究基因與環境互動關係以冀了解PTSD中此種遺傳多態性的角色。


撮要:创伤后压力症(PTSD)的形成有其环境和基因因素,其中5-HTTLPR多态性变异是一项假设性风险因素。我们使用元分析研究其中关连来显示昔日具争议性结果的情况,和增强统计学效能以查找较小效应值。我们找寻所有Pub Med和ISI数据库内的研究,但不包括2012年12月后的研究。发掘了共12项使用经历创伤样本的研究,再利用Cochrane协力回顾处理软件第五版来分析及评核其中质量和出版偏差,后使用综合元分析软件来整理元回归。综合上述所有研究,5-HTTLPR和PTSD并无关连(p = .10),但研究之间并不均一,而部份不均一性是由于性别差异。使用敏感性分析,严重创伤经历人士中SS基因型与PTSD有相连(p<.001),即SS基因型载体是严重创伤经历中PTSD的风险因素。我们必须加强研究基因与环境互动关系以了解PTSD中此种遗传多态性的角色。