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Relationship of Trauma Symptoms to Amygdala-Based Functional Brain Changes in Adolescents
Article first published online: 15 NOV 2013
Copyright © 2013 International Society for Traumatic Stress Studies
Journal of Traumatic Stress
Volume 26, Issue 6, pages 784–787, December 2013
How to Cite
Nooner, K. B., Mennes, M., Brown, S., Castellanos, F. X., Leventhal, B., Milham, M. P. and Colcombe, S. J. (2013), Relationship of Trauma Symptoms to Amygdala-Based Functional Brain Changes in Adolescents. J. Traum. Stress, 26: 784–787. doi: 10.1002/jts.21873
- Issue published online: 16 DEC 2013
- Article first published online: 15 NOV 2013
In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13–17 years with no psychiatric diagnoses. Adolescents completed a self-report trauma symptom checklist and a R-fMRI scan. We examined the relationship of trauma symptoms to resting-state functional connectivity of the amygdala. Increasing self-report of trauma symptoms by adolescents was associated with increasing functional connectivity with the right amygdala and a local limbic cluster and decreasing functional connectivity with the amygdala and a long-range frontoparietal cluster to the left amygdala, which can be a hallmark of immaturity. These pilot findings in adolescents provide preliminary evidence that even mild trauma symptoms can be linked to the configuration of brain networks associated with the amygdala.
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